Vacancy for EDITOR position to join the EIC team
Paulin Jirkof, Annemarie Lang, Jordi L. Tremoleda and José  Sanchez Morgado
pp. 390

Laboratory Animals presents Special Issue Biostatistics Notes
Romain-Daniel Gosselin and Penny S Reynolds
pp. 403

Study design: think ‘scientific value’ not ‘p-values’
Penny S Reynolds
pp. 404

Half the price, twice the gain: How to simultaneously decrease animal numbers and increase precision with good experimental design
Servan Luciano Grüninger and Florian Frommlet
pp. 411

Methods for applying blinding and randomisation in animal experiments
PS Verhave, R van Eenige and IACW Tiebosch
pp. 419

Treatment randomisation at animal or pen level?: Statistical analysis should follow the randomisation pattern!
Luc Duchateau, Robrecht Dockx, Klara Goethals, Matthijs Vynck, Frédéric Vangroenweghe and Christian Burvenich
pp. 427

Testing for normality: a user’s (cautionary) guide
Romain-Daniel Gosselin
pp. 433

Ditching the norm: Using alternative distributions for biological data analysis
Stanley E Lazic
pp. 438

Understanding p-values and significance
Naomi Altman and Martin Krzywinski
pp. 443

About statistical significance, and the lack thereof
Fulvio Magara and Benjamin Boury-Jamot
pp. 448

Depicting variability and uncertainty using intervals and error bars
Naomi Altman and Martin Krzywinski
pp. 453

Causal mediation analysis: How to avoid fooling yourself that X causes Y
Stanley E Lazic
pp. 458

Incorporating sources of correlation between outcomes: An introduction to mixed models
Limeng Liu and Ashley Petersen
pp. 463

Bayesian statistical concepts with examples from rodent toxicology studies
Gary J Larson and Keith R Shockley
pp. 470

How cage effects can hurt statistical analyses of completely randomized designs
Reid D. Landes
pp. 476

Preclinical pilot studies: Five common pitfalls and how to avoid them
Natasha A Karp, Alan Sharpe and Benjamin Phillips
pp. 481

Simulation methodologies to determine statistical power in laboratory animal research studies
Angela Jeffers, Kathryn Konrad, Gary Larson, Katherine Allen-Moyer, Helen Cunny and Keith Shockley
pp. 486

Heterogeneity of animal experiments and how to deal with it
Bernhard Voelkl and Hanno Wurbel
pp. 493

Our 61st Annual Meeting: An exciting programme is shaping up!
Jordi L. Tremoleda
pp. 499